Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning

We present the analysis of the defective genetic pathways of the Late-Onset Alzheimer’s Disease (LOAD) compared to the Mild Cognitive Impairment (MCI) and Healthy Controls (HC) using different sampling methodologies. These algorithms sample the uncertainty space that is intrinsic to any kind of high...

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Detalhes bibliográficos
Main Authors: Juan Luis Fernández-Martínez, Óscar Álvarez-Machancoses, Enrique J. de Andrés-Galiana, Guillermina Bea, Andrzej Kloczkowski
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
Alzheimer’s Disease
Mild Cognitive Impairment
Pathway analysis
Deep Pathways Sampling
Drug repositioning
Acesso em linha:https://www.mdpi.com/1422-0067/21/10/3594
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