Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry

Bispecific monoclonal antibodies (BsAbs) are engineered proteins with multiple functionalities and properties. The “bi-specificity” of these complex biopharmaceuticals is a key characteristic for the development of novel and more effective therapeutic strategies. The high structural complexity of Bs...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Christoph Gstöttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer, Simone Nicolardi
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
Colecção:mAbs
Assuntos:
Bispecific monoclonal antibody
FT-ICR mass spectrometry
MALDI-ISD
glycation
IdeS digestion
middle-up
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2019.1682403
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados