Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors

Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids, largely responsible for extracellular lysophosphatidic acid (LPA) production. LPA is a bioactive growth-factor-like lysophospholipid that exerts pleiotropic effects in almost all cell types, exerted through at least six...

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Bibliografski detalji
Glavni autori: Christiana Magkrioti, Eleanna Kaffe, Elli-Anna Stylianaki, Camelia Sidahmet, Georgia Melagraki, Antreas Afantitis, Alexios N. Matralis, Vassilis Aidinis
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-09-01
Serija:International Journal of Molecular Sciences
Teme:
atotaxin
small molecules
ATX inhibitors
in silico screening
Online pristup:https://www.mdpi.com/1422-0067/21/19/7002
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