A novel Kv1.1 potassium channel blocking toxin from the venom of Palamneus gravimanus (Indian black scorpion)

A peptide toxin was isolated from the venom of Palamneus gravimanus, the Indian black scorpion, to block human Kv1.1 channels expressed in Xenopus laevis oocytes. A 4.5 kD peptide (toxin), as confirmed by SDS-PAGE, was purified to homogeneity by ion exchange chromatography using CM-Sephadex C-25 fol...

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Main Authors: S. S. More, K. K. Mirajkar, J. R. Gadag, K. S. Menon, M. K. Mathew
Format: Artigo
Sprog:Inglês
Udgivet: SciELO 2005-09-01
Serier:Journal of Venomous Animals and Toxins including Tropical Diseases
Fag:
hKv1.1
K+ channel
PGT
TEVC
Palamneus gravimanus
Xenopus laevis oocytes
Indian black scorpion
Online adgang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300009
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