DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient

Abstract Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cell...

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Detalhes bibliográficos
Main Authors: Simona Ruggieri, Luigi Viggiano, Tiziana Annese, Carmela Rubolino, Andrea Gerbino, Roberta De Zio, Patrizia Corsi, Roberto Tamma, Domenico Ribatti, Mariella Errede, Francesca Operto, Lucia Margari, Nicoletta Resta, Silvia Di Tommaso, Jessica Rosati, Maria Trojano, Beatrice Nico
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-01-01
Colecção:Stem Cell Research & Therapy
Assuntos:
Duchenne muscular dystrophy
Dp71 dystrophin
Pluripotent stem cell
SERCA2
hiPSCs
Neurons
Acesso em linha:http://link.springer.com/article/10.1186/s13287-018-1125-5
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