Dual-Functioning Scaffolds for the Treatment of Spinal Cord Injury: Alginate Nanofibers Loaded with the Sigma 1 Receptor (S1R) Agonist RC-33 in Chitosan Films

The present work proposed a novel therapeutic platform with both neuroprotective and neuroregenerative potential to be used in the treatment of spinal cord injury (SCI). A dual-functioning scaffold for the delivery of the neuroprotective S1R agonist, RC-33, to be locally implanted at the site of SCI...

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Detalhes bibliográficos
Main Authors: Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Marta Rui, Simona Collina, Francesca Fagiani, Cristina Lanni, Franca Ferrari
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-12-01
Colecção:Marine Drugs
Assuntos:
spinal cord injury
s1r agonist
chitosan
alginate
rc-33/alg interaction product
electrospinning
film casting
mechanical properties
biodegradation
human neuroblastoma cells
Acesso em linha:https://www.mdpi.com/1660-3397/18/1/21
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