Low phosphatase activity of LiaS and strong LiaR-DNA affinity explain the unusual LiaS to LiaR in vivo stoichiometry

Abstract Background LiaRS mediates Bacillus subtilis response to cell envelope perturbations. A third protein, LiaF, has an inhibitory role over LiaRS in the absence of stimulus. Together, LiaF and LiaRS form a three-component system characterized by an unusual stoichiometry, a 4:1 ratio between Lia...

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Detalhes bibliográficos
Main Authors: Shailee Jani, Karen Sterzenbach, Vijaya Adatrao, Ghazal Tajbakhsh, Thorsten Mascher, Dasantila Golemi-Kotra
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-04-01
Colecção:BMC Microbiology
Assuntos:
Two-component system
LiaRS
Histidine kinase
Response regulator
Bacillus subtilis
Cell envelope stress
Acesso em linha:http://link.springer.com/article/10.1186/s12866-020-01796-6
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