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From reads to regions: a Bioconductor workflow to detect differential binding in ChIP-seq data [version 2; referees: 2 approved, 1 approved with reservations]

Chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq) is widely used to identify the genomic binding sites for protein of interest. Most conventional approaches to ChIP-seq data analysis involve the detection of the absolute presence (or absence) of a binding site. However, an...

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Main Authors: Aaron T. L. Lun, Gordon K. Smyth
Formáid: Artigo
Teanga:Inglês
Foilsithe: F1000 Research Ltd 2016-01-01
Sraith:F1000Research
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Rochtain Ar Líne:http://f1000research.com/articles/4-1080/v2
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