HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured. Animal models for the study of CRC-induced cachexia, in particular mo...

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Main Authors: Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2020-01-01
Series:Disease Models & Mechanisms
Assuntos:
colorectal cancer
liver metastases
hct116
cachexia
stat3
skeletal muscle
Acceso en liña:http://dmm.biologists.org/content/13/1/dmm043166
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