PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules. Combinations of chemotherapy and PEGPH20, however, have been unsuccessful in Phase III clinical trials. We hypothe...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-08-01
Colecção:Neoplasia: An International Journal for Oncology Research
Assuntos:
PEGPH20
Hypoxia
Tumor Microenvironment
Radiation Resistance
Pancreatic Cancer
Preclinical
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558622000227
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados