Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated Ferritinophagy

Tetrandrine citrate (TetC), a novel tetrandrine salt with high water solubility, demonstrates a potent antitumor activity in chronic myeloid leukemia. Studies have indicated an important role of ferroptosis in breast cancer (BC). However, whether TetC inhibits BC progression via ferroptosis has neve...

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Detalhes bibliográficos
Main Authors: Jiameng Yin, Yajun Lin, Weiwei Fang, Xin Zhang, Jie Wei, Gang Hu, Pu Liu, Jie Niu, Jun Guo, Yongzhan Zhen, Jian Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Pharmacology
Assuntos:
tetrandrine citrate
breast cancer
ferroptosis
glutathione peroxidase 4
nuclear receptor coactivator 4
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.820593/full
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