Macrophage Differentiation and Polarization Regulate the Release of the Immune Checkpoint Protein V-Domain Ig Suppressor of T Cell Activation

Recently, the V-domain immunoglobulin suppressor of T-cell activation (VISTA) was identified as a negative immune checkpoint regulator (NCR) that is mainly expressed in hematopoietic cells. Preclinical studies have shown that VISTA blockade results in impeded tumor growth and improved survival. Neve...

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Principais autores: Gaetan Aime Noubissi Nzeteu, Stephanie Schlichtner, Sulamith David, Aylin Ruppenstein, Elizaveta Fasler-Kan, Ulrike Raap, Vadim V. Sumbayev, Bernhard F. Gibbs, N. Helge Meyer
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
coleção:Frontiers in Immunology
Assuntos:
VISTA
immune checkpoint regulators
macrophage polarization
soluble immune checkpoint proteins
toll-like-receptor 4
antigen-presenting cells
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.837097/full
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