Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer′s disease

The principal pathology of Alzheimer′s disease includes neuronal extracellular deposition of amyloid-beta peptides and formation of senile plaques, which in turn induce neuroinflammation in the brain. Triptolide, a natural extract from the vine-like herb Tripterygium wilfordii Hook F, has potent ant...

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Hlavní autoři: Jian-ming Li, Yan Zhang, Liang Tang, Yong-heng Chen, Qian Gao, Mei-hua Bao, Ju Xiang, De-liang Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer Medknow Publications 2016-01-01
Edice:Neural Regeneration Research
Témata:
nerve regeneration; neurodegenerative disease; traditional Chinese medicine; Tripterygium wilfordii Hook F; triptolide; Alzheimer′s disease; amyloid plaques; amyloid-β; amyloid precursor protein; inflammation; microglia; astrocytes; neural regeneration
On-line přístup:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=9;spage=1492;epage=1498;aulast=Li
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