Amphiregulin (AREG) and Epiregulin (EREG) Gene Expression as Predictor for Overall Survival (OS) in Oxaliplatin/Fluoropyrimidine Plus Bevacizumab Treated mCRC Patients—Analysis of the Phase III AIO KRK-0207 Trial

Background: The EGFR (epithelial growth factor receptor) ligands amphiregulin (AREG) and epiregulin (EREG) have been considered as predictors for EGFR-antibody efficacy. The effect of AREG and EREG expression levels in primary tumor samples on the outcome of bevacizumab-treated patients is unknown.P...

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Detalhes bibliográficos
Main Authors: Sebastian Stintzing, Boryana Ivanova, Ingrid Ricard, Andreas Jung, Thomas Kirchner, Andrea Tannapfel, Hendrik Juette, Susanna Hegewisch-Becker, Dirk Arnold, Anke Reinacher-Schick
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-11-01
Colecção:Frontiers in Oncology
Assuntos:
colorectal cancer
maintenance
oxaliplatin
5-FU
Bevacizumab
amphiregulin
Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2018.00474/full
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