Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence

A major challenge in treating cancer is posed by intratumor heterogeneity, with different sub-populations of cancer cells within the same tumor exhibiting therapy resistance through different biological processes. These include therapy-induced dormancy (durable proliferation arrest through, e.g., po...

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Bibliographic Details
Main Authors: Razmik Mirzayans, David Murray
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
cancer therapy
cell fusion
dormancy
polyploid giant cancer cells
senescence
persister
apoptosis
anastasis
colony formation assay
high-throughput assays
Online Access:https://www.mdpi.com/1422-0067/21/4/1308
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