Dedifferentiated Endometrial Carcinoma Could be A Target for Immune Checkpoint Inhibitors (Anti PD-1/PD-L1 Antibodies)

Dedifferentiated endometrial carcinoma (DDEC) is defined as an undifferentiated carcinoma admixed with differentiated endometrioid carcinoma (Grade 1 or 2). It has poor prognosis compared with Grade 3 endometrioid adenocarcinoma and is often associated with the loss of mismatch repair (MMR) proteins...

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Auteurs principaux: Ruriko Ono, Kentaro Nakayama, Kohei Nakamura, Hitomi Yamashita, Tomoka Ishibashi, Masako Ishikawa, Toshiko Minamoto, Sultana Razia, Noriyoshi Ishikawa, Yoshiro Otsuki, Satoru Nakayama, Hideyuki Onuma, Hiroko Kurioka, Satoru Kyo
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2019-07-01
Collection:International Journal of Molecular Sciences
Sujets:
dedifferentiated endometrial carcinoma
mismatch repair deficient
microsatellite instability
endometrial cancer
immune checkpoint inhibitor
Accès en ligne:https://www.mdpi.com/1422-0067/20/15/3744
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