Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

Abstract Background Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR) is considered as one of the most pro...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil, Saleh A. Ahmed
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2019-07-01
סדרה:BMC Chemistry
נושאים:
Sulfonamide
Anticancer
Antimicrobial
Acetamides
Molecular docking
Structure–activity relationship (SAR)
גישה מקוונת:http://link.springer.com/article/10.1186/s13065-019-0603-x
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