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Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

Abstract Background Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR) is considered as one of the most pro...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil, Saleh A. Ahmed
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BMC 2019-07-01
श्रृंखला:BMC Chemistry
विषय:
ऑनलाइन पहुंच:http://link.springer.com/article/10.1186/s13065-019-0603-x
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