Multiple Regions of Kaposi’s Sarcoma-Associated Herpesvirus ORF59 RNA are Required for Its Expression Mediated by Viral ORF57 and Cellular RBM15

KSHV ORF57 (MTA) promotes RNA stability of ORF59, a viral DNA polymerase processivity factor. Here, we show that the integrity of both ORF59 RNA ends is necessary for ORF57-mediated ORF59 expression and deletion of both 5’ and 3’ regions, or one end region with a central region, of ORF59 RNA prevent...

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Hlavní autoři: Maria Julia Massimelli, Vladimir Majerciak, Jeong-Gu Kang, David J. Liewehr, Seth M. Steinberg, Zhi-Ming Zheng
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2015-02-01
Edice:Viruses
Témata:
KSHV
ORF59
ORF57
RNA accumulation
RNA export
RBM15
On-line přístup:http://www.mdpi.com/1999-4915/7/2/496
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