Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA

Abstract Background Enterobacterial common antigen (ECA) is a family-specific surface antigen shared by all members of the Enterobacteriaceae family. Previous studies showed that the loss of ECA results in Salmonella attenuation, indicating its usefulness as a vaccine candidate for Salmonella infect...

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Detalhes bibliográficos
Main Authors: Qing Liu, Xuegang Shen, Xiaoping Bian, Qingke Kong
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-06-01
Colecção:BMC Microbiology
Assuntos:
ECA
Salmonella Typhimurium
Virulence
Vaccine vector
Th2 immunity
Acesso em linha:http://link.springer.com/article/10.1186/s12866-020-01837-0
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