Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala

Converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of 5-HT synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. Here, we aimed at further elucidating the molecular mec...

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Main Authors: Magdalena T. Weidner, Roy Lardenoije, Lars Eijssen, Floriana Mogavero, Lilian P. M. T. De Groodt, Sandy Popp, Rupert Palme, Konrad U. Förstner, Tatyana Strekalova, Harry W. M. Steinbusch, Angelika G. Schmitt-Böhrer, Jeffrey C. Glennon, Jonas Waider, Daniel L. A. van den Hove, Klaus-Peter Lesch
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-05-01
Colecção:Frontiers in Neuroscience
Assuntos:
serotonin
maternal separation
mouse
emotional behavior
DNA methylation
RNA expression
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnins.2019.00460/full
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