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Feline Neural Progenitor Cells II: Use of Novel Plasmid Vector and Hybrid Promoter to Drive Expression of Glial Cell Line-Derived Neurotrophic Factor Transgene

Sustained transgene expression is required for the success of cell transplant-based gene therapy. Most widely used are lentiviral-based vectors which integrate into the host genome and thereby maintain sustained transgene expression. This requires integration into the nuclear genome, and potential r...

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Main Authors: X. Joann You, Jing Yang, Ping Gu, Chee Gee Liew, Henry J. Klassen
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2012-01-01
Colecção:Stem Cells International
Acesso em linha:http://dx.doi.org/10.1155/2012/604982
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