Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics

Gene-targeted mice with deficient AMPA receptor GluA1 subunits (Gria1-/- mice) show robust hyperlocomotion in a novel environment, suggesting them to constitute a model for hyperactivity disorders such as mania, schizophrenia and attention deficit hyperactivity disorder. This behavioral alteration h...

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Главные авторы: Teemu Aitta-aho, Milica Maksimovic, Kristiina Dahl, Rolf Sprengel, Esa R. Korpi
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019-03-01
Серии:Frontiers in Pharmacology
Предметы:
AMPA receptors
cannabidiol
DREADD
hippocampus
c-Fos
hyperactivity
Online-ссылка:https://www.frontiersin.org/article/10.3389/fphar.2019.00309/full
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