Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group. Here we studied the formation of the corresponding acyl piperidides by time-dependent monitorin...

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Bibliographic Details
Main Authors: Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio
Format: Artigo
Language:Inglês
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
piperidine
4-methylpiperidine
acyl piperidide
nmr
ir
dft
Online Access:https://www.mdpi.com/1420-3049/24/21/4004
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