Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group. Here we studied the formation of the corresponding acyl piperidides by time-dependent monitorin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2019-11-01
Cyfres:Molecules
Pynciau:
piperidine
4-methylpiperidine
acyl piperidide
nmr
ir
dft
Mynediad Ar-lein:https://www.mdpi.com/1420-3049/24/21/4004
Tagiau: Ychwanegu Tag
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