Preclinical effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines.

Osteosarcoma (OS) is the most common primary bone tumor in children and young adults. Several studies have confirmed the involvement of the IGF system in the regulation of OS cell proliferation and differentiation as well as in the protection of cells from chemotherapy. IRS-1 is a critical mediator...

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Main Authors: Cecilia eGarofalo, Mariantonietta eCapristo, Caterina eMancarella, Hadas eReuveni, Piero ePicci, Katia eScotlandi
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Endocrinology
Assuntos:
Chemotherapy, Adjuvant
Sarcoma
osteosarcoma (OS)
IGF system and signaling
IRS-1
NT157
Acceso en liña:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00074/full
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