Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer

Introduction: Pancreatic cancer (PC) is one of the most lethal tumor worldwide, with no prognosis improvement over the past 20-years. The silent progressive nature of this neoplasia hampers the early diagnosis, and the surgical resection of the tumor, thus chemotherapy remains the only available the...

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Hauptverfasser: Anna Tesei, Michela Cortesi, Sara Pignatta, Chiara Arienti, Giulio Massimo Dondio, Chiara Bigogno, Alessio Malacrida, Mariarosaria Miloso, Cristina Meregalli, Alessia Chiorazzi, Valentina Carozzi, Guido Cavaletti, Marta Rui, Annamaria Marra, Daniela Rossi, Simona Collina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-05-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
Pancreatic cancer
pan-sigma receptor modulators
endoplasmic reticulum stress
unfolded protein response
proteasome inhibition
Online Zugang:https://www.frontiersin.org/article/10.3389/fphar.2019.00490/full
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