Handling informative dropout in longitudinal analysis of health-related quality of life: application of three approaches to data from the esophageal cancer clinical trial PRODIGE 5/ACCORD 17

Abstract Background Health-related quality of life (HRQoL) has become a major endpoint to assess the clinical benefit of new therapeutic strategies in oncology clinical trials. Typically, HRQoL outcomes are analyzed using linear mixed models (LMMs). However, longitudinal analysis of HRQoL in the pre...

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Main Authors: B. Cuer, C. Mollevi, A. Anota, E. Charton, B. Juzyna, T. Conroy, C. Touraine
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-09-01
Serier:BMC Medical Research Methodology
Fag:
Pattern-mixture model
Selection model
Shared-parameters model
Joint modeling
Health-related quality of life
Informative dropout
Online adgang:http://link.springer.com/article/10.1186/s12874-020-01104-w
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