Genetic Variations of Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Our objective was to investigate the effect of ABCC2 pol...

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Autori principali: Ji Hyun Yi, Yang-Je Cho, Won-Joo Kim, Min Goo Lee, Ji Hyun Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korea Genome Organization 2013-12-01
Serie:Genomics & Informatics
Soggetti:
drug toxicity
epilepsy
genetic polymorphism
MRP2
valproic acid
Accesso online:http://genominfo.org/upload/pdf/gni-11-254.pdf
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