Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages

Trichinella infection can induce macrophages into the alternatively activated phenotype, which is primarily associated with the development of a polarized Th2 immune response. In the present study, we examined the immunomodulatory effect of T. spiralis thioredoxin peroxidase-2 (TsTPX2), a protein de...

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Autori principali: Qi-Wang Jin, Nian-Zhang Zhang, Wen-Hui Li, Hong-Tao Qin, Yin-Ju Liu, John Asekhaen Ohiolei, Dong-Yu Niu, Hong-Bin Yan, Li Li, Wan-Zhong Jia, Ming-Xin Song, Bao-Quan Fu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-09-01
Serie:Frontiers in Immunology
Soggetti:
Trichinella spiralis
thioredoxin peroxidase-2
Th2 immune responses
macrophage
alternative activation
Accesso online:https://www.frontiersin.org/article/10.3389/fimmu.2020.02015/full
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