SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis

Abstract Stimulator of interferon genes (STING) activation induces type I interferons and pro-inflammatory cytokines which stimulate tumor antigen cross presentation and the adaptive immune responses against tumor. The first-generation of STING agonists, cyclic di-nucleotide (CDN), mimicked the endo...

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Detalhes bibliográficos
Main Authors: Chunying Song, Dong Liu, Suxing Liu, Di Li, Ivana Horecny, Xinzhu Zhang, Puhui Li, Lei Chen, Matthew Miller, Rasheduzzaman Chowdhury, Mena Issa, Ru Shen, Yinfa Yan, Fengqi Zhang, Lei Zhang, Limin Zhang, Chang Bai, Jun Feng, Linghang Zhuang, Rumin Zhang, Jing Li, Hilary Wilkinson, Jian Liu, Weikang Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-05-01
Colecção:Scientific Reports
Acesso em linha:https://doi.org/10.1038/s41598-022-12449-1
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