Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic, and environmental factors are known to contribute to COPD risk and disease progression. Therefore we developed a systematic approach to identify key regulators of COPD that integrates genome-wide DNA methylation,...

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Hlavní autoři: Seungyeul Yoo, Sachiko Takikawa, Patrick Geraghty, Carmen Argmann, Joshua Campbell, Luan Lin, Tao Huang, Zhidong Tu, Robert F Foronjy, Avrum Spira, Eric E Schadt, Charles A Powell, Jun Zhu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2015-01-01
Edice:PLoS Genetics
On-line přístup:http://europepmc.org/articles/PMC4287352?pdf=render
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