In Situ Gel Formation in Microporated Skin for Enhanced Topical Delivery of Niacinamide

Although used widely in cosmetic formulations, topical delivery of niacinamide (LogP = −0.35) is unfavorable by conventional means. Poly(lactide-<i>co</i>-glycolide) (PLGA) formulations, can undergo a sol-gel transition triggered by solvent exchange, entrapping molecules and sustaining t...

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Hauptverfasser: Sonalika Bhattaccharjee, Moritz Beck-Broichsitter, Ajay K. Banga
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-05-01
Schriftenreihe:Pharmaceutics
Schlagworte:
Microneedle
Poly(lactide-co-glycolide)
In situ gel
In vitro permeation testing
Topical drug delivery
Online Zugang:https://www.mdpi.com/1999-4923/12/5/472
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