Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing

Gene editing that makes target gene modification in the genome by deletion or addition has revolutionized the era of biomedicine. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 emerged as a substantial tool due to its simplicity in use, less cost and extraordinary efficiency...

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Autores principales: Muhammad Naeem, Saman Majeed, Mubasher Zahir Hoque, Irshad Ahmad
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2020-07-01
Colección:Cells
Materias:
CRISPR/Cas9
gene targeting
targeting specificity
homology dependent repair
base editors
non-homologous end joining repair pathway
Acceso en línea:https://www.mdpi.com/2073-4409/9/7/1608
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