Quantitative or qualitative transcriptional diagnostic signatures? A case study for colorectal cancer

Abstract Background Due to experimental batch effects, the application of a quantitative transcriptional signature for disease diagnoses commonly requires inter-sample data normalization, which would be hardly applicable under common clinical settings. Many cancers might have qualitative differences...

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Hlavní autoři: Qingzhou Guan, Haidan Yan, Yanhua Chen, Baotong Zheng, Hao Cai, Jun He, Kai Song, You Guo, Lu Ao, Huaping Liu, Wenyuan Zhao, Xianlong Wang, Zheng Guo
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2018-01-01
Edice:BMC Genomics
Témata:
Classifiers
Diagnostic signature
Relative expression orderings
Platform
Batch effects
On-line přístup:http://link.springer.com/article/10.1186/s12864-018-4446-y
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