Canagliflozin inhibits vascular smooth muscle cell proliferation and migration: Role of heme oxygenase-1

Recent cardiovascular outcome trials found that sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce cardiovascular disease and mortality in type 2 diabetic patients; however, the underlying mechanisms are not fully known. Since the proliferation and migration of vascular smooth muscle cells (SM...

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Bibliographic Details
Main Authors: Ghazaleh Behnammanesh, Giovanna L. Durante, Yash P. Khanna, Kelly J. Peyton, William Durante
Format: Artigo
Language:Inglês
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Canagliflozin
Smooth muscle
Proliferation
Migration
Heme oxygenase-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720302147
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