Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251

<p>Abstract</p> <p>Glioblastoma multiforme (GBM) carries a dismal prognosis primarily due to its aggressive proliferation in the brain regulated by complex molecular mechanisms. One promising molecular target in GBM is over-expressed basic fibroblast growth factor (bFGF), which has...

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Detalhes bibliográficos
Main Authors: Zhang Biao, Feng Xuequan, Xu Xinnv, Liu Jun, Wang Jinhuan
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2011-09-01
Colecção:Journal of Experimental & Clinical Cancer Research
Assuntos:
bFGF
STAT3
IL-6
Glioblastoma multiforme
Acesso em linha:http://www.jeccr.com/content/30/1/80
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