Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice

Tristetraprolin (TTP) is a mRNA binding protein that binds to adenylate-uridylate-rich elements within the 3′ untranslated regions of certain transcripts, such as tumor necrosis factor (Tnf) mRNA, and increases their rate of decay. Modulation of TTP expression is implicated in inflammation; however,...

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Bibliographic Details
Main Authors: Ishita Choudhary, Thao Vo, Chandra S. Bathula, Richa Lamichhane, Brandon W. Lewis, Jayme Looper, Samithamby Jeyaseelan, Perry J. Blackshear, Yogesh Saini, Sonika Patial
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
tristetraprolin
Zfp36
acute lung injury
inflammation
neutrophil
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02164/full
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