Aggregation chimeras provide evidence of in vivo intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease)

The neuronal ceroid lipofuscinoses (NCLs; Batten disease) are fatal, mainly childhood, inherited neurodegenerative lysosomal storage diseases. Sheep affected with a CLN6 form display progressive regionally defined glial activation and subsequent neurodegeneration, indicating that neuroinflammation m...

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Autores principales: Lucy Anne Barry, Graham William Kay, Nadia Lesley Mitchell, Samantha Jane Murray, Nigel P. Jay, David Norris Palmer
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2022-01-01
Colección:PLoS ONE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000108/?tool=EBI
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