Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

Antibiotic resistance poses an increasingly grave threat to the public health. Of pressing concern, rapid spread of carbapenem-resistance among multidrug-resistant (MDR) Gram-negative rods (GNR) is associated with few treatment options and high mortality rates. Current antibiotic susceptibility test...

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Bibliographic Details
Main Authors: Leo Lin, Poochit Nonejuie, Jason Munguia, Andrew Hollands, Joshua Olson, Quang Dam, Monika Kumaraswamy, Heriberto Rivera Jr., Ross Corriden, Manfred Rohde, Mary E. Hensler, Michael D. Burkart, Joe Pogliano, George Sakoulas, Victor Nizet
Format: Artigo
Language:Inglês
Published: Elsevier 2015-07-01
Series:EBioMedicine
Subjects:
Azithromycin
Macrolides
Antimicrobial peptides
Cathelicidin
LL-37
Antibiotic resistance
Colistin
Pseudomonas aeruginosa
Acinetobacter baumannii
Klebsiella pneumoniae
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300244
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