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Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.

High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat diet beginning at 8 wk of age resulted in a 4-fold difference in adiposity. The phenotypes of mice characteristic of hig...

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Bibliografiske detaljer
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2006-05-01
Serier:PLoS Genetics
Online adgang:http://dx.doi.org/10.1371/journal.pgen.0020081
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