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Osteoblasts mineralization and collagen matrix are conserved upon specific Col1a2 silencing
Classical osteogenesis imperfecta (OI) is an inherited rare brittle bone disease caused by dominant mutations in the COL1A1 or COL1A2 genes, encoding for the α chains of collagen type I. The definitive cure for the disease will require a gene therapy approach, aimed to correct or suppress the mutant...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2020-05-01
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| シリーズ: | Matrix Biology Plus |
| 主題: | |
| オンライン･アクセス: | http://www.sciencedirect.com/science/article/pii/S2590028520300090 |
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