The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro

Abstract Background The use of fetal bovine serum (FBS) as a media supplement for the ex vivo expansion of bone-marrow derived mesenchymal stromal cells (BM-MSC) has been discouraged by regulatory agencies, due to the risk of transmitting zoonoses and to elicit immune reactions in the host once tran...

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Detalhes bibliográficos
Main Authors: Martina Bernardi, Francesco Agostini, Katia Chieregato, Eliana Amati, Cristina Durante, Mario Rassu, Marco Ruggeri, Sabrina Sella, Elisabetta Lombardi, Mario Mazzucato, Giuseppe Astori
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-05-01
Colecção:Journal of Translational Medicine
Assuntos:
Platelet lysate
Platelet releasate
Mesenchymal stromal cells
Mesenchymal stem cells
Ex vivo expansion
Fetal bovine serum
Acesso em linha:http://link.springer.com/article/10.1186/s12967-017-1185-9
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