AlphaFold2: A Role for Disordered Protein/Region Prediction?

The development of AlphaFold2 marked a paradigm-shift in the structural biology community. Herein, we assess the ability of AlphaFold2 to predict disordered regions against traditional sequence-based disorder predictors. We find that AlphaFold2 performs well at discriminating disordered regions, but...

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Autori principali: Carter J. Wilson, Wing-Yiu Choy, Mikko Karttunen
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-04-01
Serie:International Journal of Molecular Sciences
Soggetti:
AlphaFold2
disordered proteins
IDPs/IDRs
machine-learning
biophysics
structural bioinformatics
Accesso online:https://www.mdpi.com/1422-0067/23/9/4591
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