On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments

Abstract Background In gene expression studies, RNA sample pooling is sometimes considered because of budget constraints or lack of sufficient input material. Using microarray technology, RNA sample pooling strategies have been reported to optimize both the cost of data generation as well as the sta...

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Bibliographic Details
Main Authors: Alemu Takele Assefa, Jo Vandesompele, Olivier Thas
Format: Artigo
Language:Inglês
Published: BMC 2020-04-01
Series:BMC Genomics
Subjects:
RNA sample pooling
RNA sequencing
Differential gene expression
Experimental design
Statistical power
Cost
Online Access:http://link.springer.com/article/10.1186/s12864-020-6721-y
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