One-Pot Synthesis of α-Substituted Acrylates

Abstract A simple and efficient synthetic method towards α-substituted acrylic esters has been developed using the Horner–Wadsworth–Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as...

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Bibliographic Details
Main Authors: Magdalini Matziari, Yixin Xie
Format: Artigo
Language:Inglês
Published: Georg Thieme Verlag KG 2018-04-01
Series:SynOpen
Subjects:
acrylates
horner–wadsworth–emmons reaction
amino-acid analogues
one-pot synthesis
β-amino acids
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610357
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