The urokinase gene knockout effects on growth factor dynamics in mice with melanoma, developing on the background of chronic neurogenic pain

Purpose of the study. Studying the dynamics of growth factors (GF) in urokinase (uPA)-deficient mice with chronic neurogenic pain (CNP) and B16/F10 melanoma.Materials and methods. Levels of VEGFA, VEGFC, sVEGFRl, sVEGFR3, IGF1, IGF2, TGFp1 and FGF21 were determined by ELISA in tumors, perifocal tiss...

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Detalhes bibliográficos
Main Authors: E. M. Frantsiyants, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, V. A. Bandovkina, L. K. Trepitaki, N. D. Cheryarina, L. A. Nemashkalova, N. S. Lesovaya
Formato: Artigo
Idioma:Russo
Publicado em: QUASAR, LLC 2019-12-01
Colecção:Issledovaniâ i Praktika v Medicine
Assuntos:
mice
upa gene-knockout
b16/f10 melanoma
chronic neurogenic pain
growth factors
skin
tumor
perifocal tumor tissue
Acesso em linha:https://www.rpmj.ru/rpmj/article/view/458
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