Metabolomic Profiling of the Immune Stimulatory Effect of Eicosenoids on PMA-Differentiated THP-1 Cells

Honey bee venom has been established to have significant effect in immunotherapy. In the present study, (Z)-11-eicosenol-a major constituent of bee venom, along with its derivations methyl cis-11-eicosenoate and cis-11-eicosenoic acid, were synthesised to investigate their immune stimulatory effect...

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Main Authors: Abdulmalik M. Alqarni, Tharushi Dissanayake, David J. Nelson, John A. Parkinson, Mark J. Dufton, Valerie A. Ferro, David G. Watson
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-10-01
Colecção:Vaccines
Assuntos:
(z)-11-eicosenol
methyl cis-11-eicosenoate
cis-11-eicosenoic acid
pro- and anti-inflammatory cytokines
lps stimulation
thp-1 cells
macrophages
adjuvant vaccine
Acesso em linha:https://www.mdpi.com/2076-393X/7/4/142
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