Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model

Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replication of clinically resistant HBV strains is imperative, and...

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Bibliographic Details
Main Authors: Jingmin Zhang, Yafeng Wang, Youmei Peng, Chongzhen Qin, Yixian Liu, Jingjing Li, Jinhua Jiang, Yubing Zhou, Junbiao Chang, Qingduan Wang
Format: Artigo
Language:Inglês
Published: Elsevier 2018-11-01
Series:Brazilian Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867018304975
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