Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy

Abstract Background Corticosteroids are routinely utilized to alleviate edema in patients with intracranial lesions and are first-line agents to combat immune-related adverse events (irAEs) that arise with immune checkpoint blockade treatment. However, it is not known if or when corticosteroids can...

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Hlavní autoři: Amber J. Giles, Marsha-Kay N. D. Hutchinson, Heather M. Sonnemann, Jinkyu Jung, Peter E. Fecci, Nivedita M. Ratnam, Wei Zhang, Hua Song, Rolanda Bailey, Dionne Davis, Caitlin M. Reid, Deric M. Park, Mark R. Gilbert
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2018-06-01
Edice:Journal for ImmunoTherapy of Cancer
Témata:
Corticosteroids
Immunotherapy
Glioma
Checkpoint blockade
Dexamethasone
On-line přístup:http://link.springer.com/article/10.1186/s40425-018-0371-5
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